Cellular Senescence
Why Mayo Clinic Researchers Are Targeting Different Kinds of Senescent Cells
Mayo Clinic research shows how senescent cells differ across tissues, why some keep sending inflammatory signals and what happened when researchers targeted…
A Protein That Helps Keep Aging Cell Nuclei in Shape
Restoring β-catenin improved nuclear shape and helped cultured primate skin cells divide again. The study links two routes of protein loss to…
Experimental Vaccine Targeting Aging Cells Extended Median Lifespan in Mice
An experimental nanovaccine increased median lifespan by about 12% in small groups of female mice. Short-lived controls, uncertain targeting and long-term safety…
Why Do We Age If Our Cells Keep Replacing Themselves?
Cell replacement varies across the body. Long-lived cells, inherited DNA changes and aging tissue help explain why ongoing renewal does not prevent…
A New Human Cell Atlas Reveals How Blood Vessels Change With Age
An atlas of 375,829 human endothelial cells maps shared and tissue-specific aging signals, offering a research resource rather than a proven treatment.
An RNA-Regulating Protein Helped Preserve Aging Blood-Vessel Cells
MTR4 experiments changed senescence markers in cultured human endothelial cells and vascular measures in mice. Lifespan findings came from worms.
Restoring Cellular Cleanup Reduced Senescent Cells in Aged Mice
A Nature Aging study links a declining protein-cleanup pathway to failed immune clearance. An experimental activator reduced senescence-related changes in mice, but…
The “Guardian Paradox” Proposes a Link Between Chronic DNA Damage Signaling and Aging
A review proposes that DNA damage-response pathways can become chronically overactive with age, connecting cellular senescence, inflammation and stem-cell decline. It is…
Raman Microscopy and AI Reveal Senescence Signatures in Mouse Tissue
RamanOmics links chemical fingerprints with gene activity to study senescent cells. The mouse study advances measurement, but does not establish a noninvasive…
Insilico Wants to Build a “Longevity Vaccine.” Here’s What Actually Exists So Far
Insilico’s “Longevity Vaccines” initiative proposes programming immune cells inside the body. Related mouse studies are encouraging, but the announcement offers no programme-specific…