Medicine
Clinical trials, drugs, diagnostics and medical interventions related to aging, healthspan and age-related disease, assessed without hype.
Common Cholesterol Drugs Were Linked to Slower Bone Loss After Menopause
Two cohorts totaling 169 postmenopausal women linked statin use to slower spinal bone-density loss. Mouse and cell experiments suggest a mechanism, without…
Lilly Reports Retatrutide Outperformed Ozempic 2 mg in a Phase 3 Diabetes Trial
Lilly reports greater blood-sugar and weight reductions with retatrutide than Ozempic 2 mg. The topline results concern diabetes, not longevity; retatrutide remains…
Whatever Happened to Metformin as an Anti-Aging Drug?
Metformin’s longevity promise has met mixed human trial results. We trace the mouse experiments, TAME plans, exercise findings and a new frailty…
An Immune Pathway May Connect Aging Bone Marrow to Bone Loss
Mouse experiments connect marrow fat, STING inflammation and NAD+ depletion with impaired bone formation. Human treatment benefits remain unproven.
Menopause May Coincide With an Abrupt, Body-Wide Physiological Shift
A study of more than 300 million laboratory results links menopause timing to shifts across multiple body systems. Its hormone therapy findings…
Senolytics Improved Liver Fibrosis in a Small Randomized Human Trial
A small randomized trial found improved liver fibrosis with dasatinib plus quercetin in people with MASH. The disease signal is encouraging, but…
FDA Officials Discuss How Longevity Drugs Could Be Evaluated
FDA officials at ARDD discussed possible evidence standards for longevity drugs. The conversation concerns regulatory science, not recognition of aging as a…
Targeting BIRC6 Improved Aging Blood Stem Cells and Vaccine Response in Mice
A BIRC6-targeted nanoparticle shifted blood-cell production and strengthened vaccine responses in middle-aged mice. Human stem cells responded ex vivo, but no people…
AgelessRx Says a 90-Day Longevity Trial Improved Healthspan. What Did It Actually Show?
AgelessRx reported favorable changes from an 18-person final analysis. The randomized pilot generated signals, but it did not prove slower aging or…
Can Stem Cells Treat Frailty? A New Human Trial Tests the Idea
A randomized Phase 2b trial found that one laromestrocel infusion improved walking distance at nine months. It is promising human evidence, not…