Medicine
Clinical trials, drugs, diagnostics and medical interventions related to aging, healthspan and age-related disease, assessed without hype.
Semaglutide Extended Lifespan in Old Mice. Does That Make It a Longevity Drug?
Semaglutide extended median lifespan by about 12% in older female mice. The result is compelling animal evidence, not proof of a human…
Scientists Find a Tiny Protein That May Help Protect the Aging Heart
A 47-amino-acid mitochondrial protein helped preserve heart structure and function in experimental models, but it is not an anti-aging treatment for people.
The Ovary May Be Keeping Track of How Many Eggs Remain
A 3D map of more than 85,000 mouse oocytes found that roughly 14% of the remaining reserve stayed in a transitional state…
Whatever Happened to Senolytics?
Senolytics were once expected to clear the “zombie cells” of aging. A decade of human trials has produced intriguing biological signals, major…
A Startup Says It Can Make Your Blood Younger. Where’s the Evidence?
Generation Lab says an undisclosed two-drug injection can make the body’s systemic environment younger. The scientific premise is plausible, but controlled human…
Sam Altman-Backed Retro Biosciences Moves Deeper Into Human Testing
Sam Altman-backed Retro Biosciences is advancing RTR242 through a Phase 1 trial in healthy volunteers. Here is what the trial can show,…
Your Eyes May Reveal How Fast You’re Aging: AI Finds a Retinal Signal in 71,000 People
AI estimated age from retinal photographs in 71,343 people. An older retinal signal tracked several health risks, but it is not a…
Brain Aging May Not Be Just About Neurons. Myelin-Making Cells Could Be Part of the Problem
Human brain tissue and mouse experiments point to oligodendrocytes, myelin and NRF2 as possible contributors to cognitive decline. No human treatment has…
Two Common Age-Related Changes in Blood Cells Are Linked to Mortality
In 205,543 men, CHIP and mosaic loss of the Y chromosome were independently associated with mortality. The study found no clear evidence…
People Who Reach 110 Have an Unusual Immune Feature
A small observational study found expanded CD4 cytotoxic T-cell clones in supercentenarians. The cells are intriguing, but they are not proven to…