Medicine
Two Common Age-Related Changes in Blood Cells Are Linked to Mortality
In 205,543 men, CHIP and mosaic loss of the Y chromosome were independently associated with mortality. The study found no clear evidence…
People Who Reach 110 Have an Unusual Immune Feature
A small observational study found expanded CD4 cytotoxic T-cell clones in supercentenarians. The cells are intriguing, but they are not proven to…
Why Aging T Cells Struggle to Fight Cancer, and Two Genes That May Help Explain It
CRISPR screening identified DUSP5 and ZNF219 as regulators of age-related T-cell dysfunction in mouse tumors. Human evidence remains observational.
A New Aging Clock Measures the Colon. Disease Seems to Speed It Up.
A tissue-specific DNA methylation clock estimated colon age with a 3.9-year mean error. Disease groups looked older, but the clock is not…
Longevity Medicine Is Arriving Before Primary Care Is Ready
Patients are asking doctors about aging clocks, rapamycin and senolytics before medicine has settled what to test, prescribe or monitor. Primary care…
Rapamycin + Resveratrol for Your Skin? What the Evidence Actually Shows
Agency Skin is pairing rapamycin with resveratrol in a prescription formula. The mechanism is plausible, but the exact combination lacks a published…
The Peptide Boom: What the Evidence Actually Says
Peptide clinics promise faster healing, more muscle and slower aging. We compare 20 popular compounds, their purported benefits, human evidence, side effects…
Does fasting become riskier with age? What a 15-year study actually found
A 15-year study linked longer daily meal gaps to faster disease accumulation in older adults, especially after age 78. Here’s what it…
A Peptide Strategy Extended Survival in a Progeria Mouse Model
A peptide stabilized a chromatin protein, reduced cellular senescence and extended survival in mice with a progeria mutation.
Personalized mRNA Cancer Vaccine Clears Phase 3 Test. Here’s What We Still Don’t Know
A personalized mRNA therapy improved recurrence-free and distant metastasis-free survival in a Phase 3 melanoma trial—but effect size and overall-survival data remain…