Mouse Studies
Experimental Vaccine Targeting Aging Cells Extended Median Lifespan in Mice
An experimental nanovaccine increased median lifespan by about 12% in small groups of female mice. Short-lived controls, uncertain targeting and long-term safety…
Common Cholesterol Drugs Were Linked to Slower Bone Loss After Menopause
Two cohorts totaling 169 postmenopausal women linked statin use to slower spinal bone-density loss. Mouse and cell experiments suggest a mechanism, without…
A Protein in Brain Support Cells May Influence Aging Throughout the Body
Increasing FGF13 in brain support cells improved memory tests and reduced inflammatory and senescence markers in mice. Human benefits remain unproven.
Tiny Structures on Brain Cells May Help Explain Calorie Restriction’s Effects
Cell and mouse experiments link hypothalamic cilia to NAD+ and lysosomal function. Disrupting cilia weakened selected benefits of calorie restriction.
An RNA-Regulating Protein Helped Preserve Aging Blood-Vessel Cells
MTR4 experiments changed senescence markers in cultured human endothelial cells and vascular measures in mice. Lifespan findings came from worms.
PLA2G2F Offers a Clue to Memory Resilience in Aging Mice
Boosting PLA2G2F protected spatial memory in aged mice. Human brain associations and laboratory cell findings do not establish a dementia treatment.
An Immune Pathway May Connect Aging Bone Marrow to Bone Loss
Mouse experiments connect marrow fat, STING inflammation and NAD+ depletion with impaired bone formation. Human treatment benefits remain unproven.
Restoring a Brain Protein Improved Memory and Lifespan in Mice
A mouse study linked hypothalamic Menin to aging and cognition. Restoring the protein improved several measures, while D-serine improved memory. Human treatment…
Restoring Cellular Cleanup Reduced Senescent Cells in Aged Mice
A Nature Aging study links a declining protein-cleanup pathway to failed immune clearance. An experimental activator reduced senescence-related changes in mice, but…
Longevica Wants to Turn a 16,000-Animal Longevity Screen Into New Drugs
Longevica says a $13 million screen tested 1,033 compounds in more than 16,000 mice. Its new advisory board may help build a…